It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, where cells make proteins necessary for mitosis and replicate their DNA.

Nov 13, 2025 · CDK2 (Cyclin Dependent Kinase 2) is a Protein Coding gene. Diseases associated with CDK2 include Endometrial Hyperplasia and Laryngeal Squamous Cell Carcinoma. Among its related …

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Feb 9, 2025 · Cyclin dependent kinase 2 (CDK2) regulates cell cycle and is an emerging target for cancer therapy.

Apr 17, 2020 · Cyclin-dependent kinase 2 (CDK2) controls cell division and is central to oncogenic signaling. We used an “in situ” approach to identify CDK2 substrates within nuclei isolated from cells …

Cyclin-dependent kinase 2 (CDK2) is defined as a key regulator of the cell cycle that interacts with and phosphorylates proteins involved in various biological processes, including DNA damage response …

Jun 1, 2023 · CDK2 is a core cell-cycle kinase that phosphorylates many substrates to drive progression through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an attractive …

Like other protein kinases, Cdk2 is composed of two lobes: a smaller amino-terminal lobe (top) that is composed primarily of beta sheet and the PSTAIRE helix, and a large carboxy-terminal lobe (bottom) …

Jan 10, 2025 · Cyclin dependent kinase 2 (CDK2) is responsible for enforcing progression through the G1-S phase transition. Mutations and alterations in the CDK2 signaling pathway are associated with …

May 20, 2022 · Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against CDK2 …